度他雄胺,≥99%
【编号】:125351 【产品名称】:度他雄胺,≥99% 【规格】:10MG 【用途】: 度他雄胺,≥99%
Product Name: Dutasteride
CAS号:164656-23-9
分子量:528.53
贮存: 储存温度-20°C
可溶性: 25°C: DMSO 62 mg/mL; Water <1 mg/mL; Ethanol 6 mg/mL
生化和生理学机理:
Description:
IC50 Value: N/A
Dutasteride(GG745) is a potent inhibitor of both 5alpha-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT.
in vitro: Dutasteride inhibited (3)H-T conversion to (3)H-DHT and, as anticipated, inhibited T-induced secretion of PSA and proliferation. However the drug also inhibited DHT-induced PSA secretion and cell proliferation (IC(50) approximately 1 microM). Dutasteride competed for binding the LNCaP cell AR with an IC(50) approximately 1.5 microM. High concentrations of dutasteride (10-50 microM), but not finasteride, in steroid-free medium, resulted in enhanced cell death, possibly by apoptosis [1]. Dutasteride reduces cell viability and cell proliferation in both cell lines tested (androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human prostate cancer (PCa)) [2].www.atcc360.com
in vivo: GG745 has a terminal half-life of approximately 240 h
|
上一篇:卡泊三醇,≥99% | 下一篇:Edoxaban, ≥99% |
---|
热销产品 新品上架