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PR-619, ≥99%
  【编号】:126704

  【产品名称】:PR-619, ≥99%

  【规格】:25MG

  【用途】:

  PR-619, ≥99%

  Product Name: PR-619
  CAS号:2645-32-1
  分子量:223.28
  介绍: PR-619
  贮存: 储存温度-20°C
  可溶性: 25°C: DMSO 45 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL
  生化和生理学机理:
  Description:
  IC50 Value: 3.93 μM (EC50, USP4); 7.2 μM (EC50, USP2 core); 5.10 μM (EC50, USP20) [1]
  PR-619 is a broad-range DUB inhibitor with potential for further development as a chemotherapeutic agent in cancer therapy.
  in vitro: PR-619 induces HCT116 cell death with EC50 values of 6.3 μM [1]. The general deubiquitylase (DUB) inhibitor, PR-619 attenuated KCa3.1 degradation, indicative of deubiquitylation being required for lysosomal delivery [2]. Proteasome inhibition by MG-132 and deubiquitinase inhibition by PR-619 induces significant changes to the ubiquitin landscape, but that not all ubiquitination sites regulated by MG-132 and PR-619 are likely substrates for the ubiquitin-proteasome system [3]. Cells were incubated with PR-619, a broad-range, reversible inhibitor of ubiquitin isopeptidases. Incubation with PR-619 led to morphological changes, the upregulation of heat shock proteins (HSP), including HSP70 and αB-crystallin, andwww.atcc360.com
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