泛昔洛韦, ≥99%
【编号】:129240 【产品名称】:泛昔洛韦, ≥99% 【规格】:50MG 【用途】: 泛昔洛韦, ≥99%
Product Name: Famciclovir
别名:2-[2-(2-氨基-9H-嘌呤-9-基)乙基]-1,3-丙二醇二乙酯
CAS号:104227-87-4
分子式:C14H19N5O4
分子量:321.33
介绍: Famciclovir
贮存: 储存温度-20°C
可溶性:
DMSO 64 mg/mL
Water 64 mg/mL
Ethanol 48 mg/mL
生化和生理学机理:
Description: IC50 Value: Refer to penciclovir Famciclovir is the diacetyl 6-deoxy analog of the active antiviral compound penciclovir with potential use in the treatment of infections caused by the herpes family of viruses [1]. Famciclovir, a synthetic acyclic guanine derivative, is a prodrug which, after oral administration, is rapidly metabolised to the highly bioavailable antiviral compound penciclovir [2]. in vitro: Famciclovir induced rapid, dose-dependent suppression of viral replication and reduction in alanine aminotransferase (ALT), with greatest efficacy in the 500-mg tid treatment group. HBV DNA reduction was maintained throughout the treatment period. ALT also steadily declined during the treatment period [3]. in vivo: In rat, following dosing at 40 mg/kg, famciclovir was rapidly and extensively metabolized to the active antiviral compound penciclovir, which reached peak concentrations in the plasma (mean 3.5 micrograms/ml) at 0.5 h [4]. Necrotic hepatitis
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