Talarozole, ≥99%
| 【编号】：126654 【产品名称】：Talarozole, ≥99% 【规格】：5MG 【用途】：   Talarozole, ≥99%
Product Name： Talarozole
CAS号：201410-53-9
分子式：C21H23N5S
分子量：377.51
贮存： 储存温度-20°C
可溶性： 25°C： DMSO
生化和生理学机理：
Description： IC50 Value：N/A Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne[2]. in vitro： Talarozole treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1]. in vivo： Talarozole slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the hal
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