当前位置:对照品 > 实验试剂 > 生化试剂 >
Reversine, ≥98%(HPLC)
  【编号】:126916

  【产品名称】:Reversine, ≥98%(HPLC)

  【规格】:5MG

  【用途】:

  Reversine, ≥98%(HPLC)

  Product Name: Reversine
  CAS号:656820-32-5
  分子式:C21H27N7O
  分子量:393.49
  介绍: Reversine
  贮存: 储存温度-20°C
  可溶性: 25°C: DMSO
  生化和生理学机理:
  Description:
  IC50 Value: 150 nM (Aurora Kinase A); 500 (Aurora Kinase B); 400 nM (Aurora Kinase C) [1]
  Reversine, a small synthetic purine analogue (2,6-disubstituted purine), has been shown to be effective in tumor suppression. These effects of reversine are due to the inhibition of Aurora A and B.
  in vitro: Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9. Use of a pan-caspase inhibitor before treatment with reversine attenuated cell death [2]. Reversine significantly suppressed the proliferation of two OSCC cell lines (OC2 and OCSL) and markedly rendered cell cycle arrest at G2/M stage. Reversine also induced cell death via both caspase-dependent and -independent apoptosis. In addition,reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy [3]. Reversine pre-treatment, at very low concentration (50 nM), caused a marked increase in the differentiation yiel
上一篇:Orteronel, ≥99% 下一篇:Riociguat, ≥99%



    
    首 页 | 对照品| 标准品| 标准物质| 实验试剂| 培养基| 菌种购买| 新闻中心| 联系我们| 网站地图

    2011-2018 北京莱耀生物版权所有豫ICP备17046142号