盐霉素，≥98％
| 【编号】：126053 【产品名称】：盐霉素，≥98％ 【规格】：5MG 【用途】：   盐霉素，≥98％
Product Name： Salinomycin
CAS号：53003-10-4
分子式：C42H70O11
分子量：751
介绍： 盐霉素
贮存： 储存温度-20°C
可溶性： DMSO
生化和生理学机理：
Description： IC50 Value： Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways[1]. in vitro： Salinomycin acts as a potassium ionophore and thereby interferes with transmembrane potassium potential, leading to mitochondrial and cellular potassium efflux. low concentrations of Salinomycin of 1 μM and 2 μM resulted in haggard and less confluent grown cells, increasing concentrations of Salinomycin of 5 μM and 10 μM resulted in a globular and defragmented cellular phenotype[2]. Treatment of 10.2 ?M Sal for 48 h caused G0/G1 cell cycle arrest in HepG2 cells, whereas 15.3 ?M Sal and 13.8 ?M Sal for 48 h induced G2/M phase arrest in SMMC-7721 and BEL-7402 cells, respectively[3]. in vivo： After administration of 4 mg/kg Sal, 8 mg/kg Sal and 10 ul/g saline wa
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