Tanaproget, ≥99%
【编号】:125113 【产品名称】:Tanaproget, ≥99% 【规格】:5MG 【用途】: Tanaproget, ≥99%
Product Name: Tanaproget
CAS号:304853-42-7
分子式:C16H15N3OS
分子量:297.37
贮存: 储存温度-20°C
可溶性: 25°C: DMSO
生化和生理学机理:
Description:
IC50 Value: 0.1 nM (EC50, induce alkaline phosphatase activity) [1]
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins. Tanaproget represents a potential first-in-class nonsteroidal PR agonist for contraception with improved safety and side effect profiles versus currently available steroidal oral contraceptives.
in vitro: In T47D cells, TNPR induces alkaline phosphatase activity with an EC(50) value of 0.1 nm, comparable with potent steroidal progestins such as medroxyprogesterone acetate (MPA) and trimegestone (TMG), albeit with a reduced efficacy ( approximately 60%). In a mammalian two-hybrid assay to measure PR agonist-induced interaction between steroid receptor co-activator-1 and PR, TNPR showed similar potency (EC(50) value of 0.02 nm) and efficacy to MPA and TMG [1].
in vivo: TNPR effectively down-regu
|
上一篇:SQ109, ≥99% | 下一篇:噻奈普汀,≥99% |
---|
热销产品 新品上架