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Tanaproget, ≥99%
  【编号】:125113

  【产品名称】:Tanaproget, ≥99%

  【规格】:5MG

  【用途】:

  Tanaproget, ≥99%

  Product Name: Tanaproget
  CAS号:304853-42-7
  分子式:C16H15N3OS
  分子量:297.37
  贮存: 储存温度-20°C
  可溶性: 25°C: DMSO
  生化和生理学机理:
  Description:
  IC50 Value: 0.1 nM (EC50, induce alkaline phosphatase activity) [1]
  Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins. Tanaproget represents a potential first-in-class nonsteroidal PR agonist for contraception with improved safety and side effect profiles versus currently available steroidal oral contraceptives.
  in vitro: In T47D cells, TNPR induces alkaline phosphatase activity with an EC(50) value of 0.1 nm, comparable with potent steroidal progestins such as medroxyprogesterone acetate (MPA) and trimegestone (TMG), albeit with a reduced efficacy ( approximately 60%). In a mammalian two-hybrid assay to measure PR agonist-induced interaction between steroid receptor co-activator-1 and PR, TNPR showed similar potency (EC(50) value of 0.02 nm) and efficacy to MPA and TMG [1].
  in vivo: TNPR effectively down-regu
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