PRX-08066
【编号】:127869 【产品名称】:PRX-08066 【规格】:5MG 【用途】: PRX-08066
Product Name: PRX-08066
CAS号:866206-54-4
分子式:C19H17ClFN5S
分子量:401.89
贮存: 储存温度-20°C
可溶性: DMSO
生化和生理学机理:
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist that causes selective vasodilation of pulmonary arteries. PRX-08066 significantly reduced peak PA pressure at 50 and 100 mg/kg (P < 0.05 and < 0.01, respectively) compared with MCT control animals. The 5-HT2BR antagonist PRX-08066 significantly attenuated the elevation in PA pressure and RV hypertrophy and maintained cardiac function. PRX-08066 prevents the severity of PAH in the MCT rat model.
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