UNC1215, ≥99%
| 【编号】：125324 【产品名称】：UNC1215, ≥99% 【规格】：5MG 【用途】：   UNC1215, ≥99%
Product Name： UNC1215
CAS号：1415800-43-9
分子式：C32H43N5O2
分子量：529.72
贮存： 储存温度-20°C
可溶性： 25°C： DMSO
生化和生理学机理：
Description：
IC50 Value： 120 nM [1]
UNC1215 is a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptional repressors.
in vitro： UNC1215 binds L3MBTL3 with a K(d) of 120 nM, competitively displacing mono- or dimethyllysine-containing peptides, and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family while also demonstrating selectivity against more than 200 other reader domains examined. X-ray crystallography identified a unique 2：2 polyvalent mode of interaction between UNC1215 and L3MBTL3. In cells, UNC1215 is nontoxic and directly binds L3MBTL3 via the Kme-binding pocket of the MBT domains. UNC1215 increases the cellular mobility of GFP-L3MBTL3 fusion proteins, and point mutants that disrupt the Kme-binding function of GFP-L3MBTL3 phenocopy the effects of UNC1215 on localization [1].
in vivo： N/A
Toxicity： N/A
Clinical trial： N/A
|
| 上一篇：他扎罗汀，≥98％ | 下一篇：Vc-MMAD, ≥99% |
|---|
热销产品 新品上架