产品编号：129278
产品规格：50MG
产品价格：2000
产品详情
盐酸特比萘酚, ≥98%
Product Name： Terbinafine HCl
别名：特比萘芬盐酸盐;反-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘基甲胺盐酸盐;(E)-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐;(E)-N-(6,6-二甲基庚-2-烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐
CAS号：78628-80-5
分子式：C21H25N·HCl
分子量：327.89
介绍： Terbinafine 盐酸盐
贮存： 储存温度-20°C
可溶性：
DMSO 66 mg/mL
Water <1 mg/mL
Ethanol 66 mg/mL
生化和生理学机理：
Terbinafine hydrochloride is a synthetic allylamine antifungal, which is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. Terbinafine hydrochloride is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch, inhibiting ergosterol synthesis at the stage of squalene epoxidation (IC50 = 30 nM for C. albicans). Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. At 90-120 ?M, Terbinafine exhibits anti-tumor and anti-angiogenic activity by inducing cell cycle arrest at the G0/G1 stage in COLO 205 tumor cells and human vascular endothelial cells.
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