普拉西坦标准品

  【编号】：VIP(P)226924

  【产品名称】：普拉西坦标准品

  【规格】：10mg

  【价格】：240元

　　普拉西坦标准品

　　Product Name： Pramiracetam

　　CAS号：68497-62-1

　　分子式：C14H27N3O2

　　分子量：269.38

　　贮存：储存温度-20°C

　　可溶性：

　　DMSO 54 mg/mL

　　Water <1 mg/mL

　　Ethanol <1 mg/mL

　　生化和生理学机理：

　　Description：

　　IC50 Value： N/A

　　Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries.

　　in vitro： Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1].

　　in vivo： In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (+/- SD) peak plasma concentrations of the four dose groups (2.71 +/- 0.54, 5.40 +/- 1.34, 6.13 +/- 0.71, 8.98 +/- 0.71 micrograms/mL) were attained between two to three hours following drug administration [2]. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food [3].

　　Toxicity： N/A

　　Clinical trial： N/A

上一篇：Preladenant, ≥98%		下一篇：PF-04447943

普拉西坦标准品

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