白介素1受体拮抗剂（IL-1ra）（人类，rDNA衍生）

  【编号】：NIBSC92/644

  【名称】：白介素1受体拮抗剂（IL-1ra）（人类，rDNA衍生）

  【规格】：支

  【价格】：2200元

　　白介素1受体拮抗剂（IL-1ra）（人类，rDNA衍生）

　　编号：NIBSC92/644

　　英文：Interleukin-1 Receptor Antagonist (IL-1ra) (Human, rDNA derived)

　　中文：白介素1受体拮抗剂

　　标准类型：非世卫组织参考材料

　　规格：1ml

　　描述：1. INTENDED USE

2. CAUTION

This preparation is not for administration to humans or animals in

the human food chain.

The preparation contains material of human origin, and either the final

product or the source materials, from which it is derived, have been

tested and found negative for HBsAg, anti-HIV and HCV RNA. As with

all materials of biological origin, this preparation should be regarded as

potentially hazardous to health. It should be used and discarded

according to your own laboratory's safety procedures. Such safety

procedures should include the wearing of protective gloves and

avoiding the generation of aerosols. Care should be exercised in

opening ampoules or vials, to avoid cuts.

3. UNITAGE

Each ampoule contains approximately 10.0 micrograms IL-1ra. The

assigned potency is 10 milli-units per ampoule.

4. CONTENTS

Country of origin of biological material: United Kingdom.

Each ampoule contains the residue after freeze drying of 1ml of a solution

that contained:

10.0 micrograms IL-1ra

3.0mg Trehalose

1.0 mg human serum albumin

5x10-2 mol/l sodium phosphate buffer

5. STORAGE

For economy of use, it is recommended that the solution be

sub-divided into several small aliquots and stored at -40oC or below.

Avoid repeated thawing/freezing.

Please note: because of the inherent stability of lyophilized material,

NIBSC may ship these materials at ambient temperature.

6. DIRECTIONS FOR OPENING

DIN ampoules have an 'easy-open' coloured stress point, where the

narrow ampoule stem joins the wider ampoule body. Various types of

ampoule breaker are available commercially. To open the ampoule,

tap the ampoule gently to collect material at the bottom (labelled) end

and follow manufactures instructions provided with the ampoule

breaker.

7. USE OF MATERIAL

No attempt should be made to weigh out any portion of the freeze-dried

material prior to reconstitution

Dissolve the total contents of the ampoule in a known volume of a suitable

solvent (distilled water, buffer or saline). Further dilutions should be made

in a medium containing carrier protein.

8. STABILITY

Reference materials are held at NIBSC within assured, temperaturecontrolled

storage facilities and they should be stored on receipt as

indicated on the label. An arbitrary unitage was assigned to this

preparation at the time of production without confirmation of long termstability. Evidence from similar materials prepared by an equivalent

process indicates that long term stability is likely to be maintained and the

material is suitably stable for shipment at ambient temperature without

any effect on the assigned values. Once reconstituted, diluted or

aliquoted, users should determine the stability of the material according

to their own method of preparation, storage and use. Users who have

data supporting any deterioration in the characteristics of any reference

preparation are encouraged to contact NIBSC.

9. REFERENCES

This standard was produced under WHO guidelines cited in the WHO

Technical Reports Series 1990 No.800 Annex 4.

10. ACKNOWLEDGEMENTS

The IL-1ra contained in this ampoule was selected from preparations

generously contributed by Synergen Inc. and The Upjohn Co. to NIBSC,

which is a WHO International Laboratory for Biological Standards.

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白介素1受体拮抗剂（IL-1ra）（人类，rDNA衍生）

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